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	Provedor de dados BABT (1) BJID (1) Genet. Mol. Biol. (1) Autor Costa,Elaine (3) Alvarez,Patrícia (2) Andrade,Elisabete (2) Brindeiro,Rodrigo (2) Ferreira,Antonio G.P. (2) Fontana-Maurell,Marcela (2) Ribeiro,Marisa (2) Rocha,Daniele (2) Tanuri,Amilcar (2) Barbisan,Luis Fernando (1) Bueno,Aline (1) Calderon,Iracema Mattos Paranhos (1) Damasceno,Débora Cristina (1) Godoy,Daniela Tupy de (1) Rodrigues,Marcela Marcondes Pinto (1) Rudge,Marilza Vieira Cunha (1) Saito,Felipe Hiroshi (1) de Godoy,Daniela Tupy (1) Mais... Palavra-chave Apoptosis (1) Blood donors (1) Cell proliferation (1) Diabetes (1) Direct-acting antivirals (1) HCV (1) IUGR (1) Monitoring patients (1) NS3 (1) NS5b (1) Placenta (1) Rat (1) Real Time PCR (1) Resistance-associated substitutions (1) Viral load (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2020 (1) 2018 (1) 2012 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Evaluation of cell proliferation and apoptosis in placentas of rats with severe diabetes BABT Rudge,Marilza Vieira Cunha; Costa,Elaine; Barbisan,Luis Fernando; Damasceno,Débora Cristina; Bueno,Aline; Saito,Felipe Hiroshi; Calderon,Iracema Mattos Paranhos; Rodrigues,Marcela Marcondes Pinto. The aim of this work was to analyze the cell proliferation and apoptosis indexes on the 18th and 21st days of pregnancy of diabetic rats and to correlate with maternal glycemia and perinatal outcomes. Placentas from 20 Wistar rats were collected and divided into four experimental groups: control and diabetic of 18 and 21 days of pregnancy. The cell proliferation was analyzed using the PCNA expression and apoptosis by the TUNEL method. It was observed that PCNA and TUNEL indexes decreased from day 18 to 21 of pregnancy in the placentas of diabetic rats and these values were lower than control groups. Diabetic dams presented higher percentage of small for pregnancy age (SPA) fetuses. However, there was no difference between the PCNA and TUNEL indexes in SPA... Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; Cell proliferation; Apoptosis; Placenta; Rat; IUGR. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200009 One-step real-time PCR assay for detection and quantification of RNA HCV to monitor patients under treatment in Brazil BJID Andrade,Elisabete; Rocha,Daniele; Fontana-Maurell,Marcela; Costa,Elaine; Ribeiro,Marisa; de Godoy,Daniela Tupy; Ferreira,Antonio G.P.; Tanuri,Amilcar; Alvarez,Patrícia; Brindeiro,Rodrigo. ABSTRACT The Brazilian Public Health Service provides freely αPEG-IFN to treat patients infected with HCV. The primary goal of HCV therapy is the long-term elimination of HCV from the blood to reduce the risk of HCV associated complications and death. Patient viremia affects the treatment duration and response, thus influencing clinical decisions. We developed a high-throughput method to perform the quantification of RNA hepatitis C virus (HCV) virus load in plasma samples to monitor patients under treatment. The method is based on a duplex detection, in a one-step real-time RT-PCR assay and it has been validated according to the rules established by the official Brazilian regulatory agency (ANVISA). This new method was compared to a commercial kit... Tipo: Info:eu-repo/semantics/article Palavras-chave: HCV; Viral load; Real Time PCR; Monitoring patients. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500418 Resistance mutations of NS3 and NS5b in treatment-naïve patients infected with hepatitis C virus in Santa Catarina and Rio Grande do Sul states, Brazil Genet. Mol. Biol. Andrade,Elisabete; Rocha,Daniele; Fontana-Maurell,Marcela; Costa,Elaine; Ribeiro,Marisa; Godoy,Daniela Tupy de; Ferreira,Antonio G.P.; Tanuri,Amilcar; Brindeiro,Rodrigo; Alvarez,Patrícia. Abstract Hepatitis C virus (HCV) infection is a worldwide health problem. Nowadays, direct-acting antiviral agents (DAAs) are the main treatment for HCV; however, the high level of virus variability leads to the development of resistance-associated variants (RAVs). Thus, assessing RAVs in infected patients is important for monitoring treatment efficacy. The aim of our study was to investigate the presence of naturally occurring resistance mutations in HCV NS3 and NS5 regions in treatment-naïve patients. Ninety-six anti-HCV positive serum samples from blood donors at the Center of Hematology and Hemotherapy of Santa Catarina State (HEMOSC) were collected retrospectively in 2013 and evaluated in this study. HCV 1a (37.9%), 1b (25.3%), and 3a (36.8%) subtypes... Tipo: Info:eu-repo/semantics/article Palavras-chave: Direct-acting antivirals; Resistance-associated substitutions; Blood donors; NS3; NS5b. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100107 Registros recuperados: 3 Primeira ... 1 ... Última

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